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Cdc25C Antibody (PA5-95316) in WB
Western blot analysis of Cdc25C in Lane 1: rat ovary tissue lysate (50 µg), Lane 2: rat liver tissue lysate (50 µg), Lane 3: HeLa whole cell lysate (40 µg), Lane 4: SW620 whole cell lysate (40 µg). Samples were incubated with Cdc25C polyclonal antibody (Product # PA5-95316).
产品信息
PA5-95316
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E.coli-derived human Cdc25C recombinant protein (Position: K175-P473).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Affinity chromatography
保存液
PBS with 5mg BSA
内含物
0.05mg sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2807119
产品详细信息
Human Cdc25C shares 78.2% amino acid (aa) sequence identity with mouse Cdc25C.
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
靶标信息
M-phase inducer phosphatase 3is an enzyme that in humans is encoded by theCDC25Cgene. This gene is highly conserved during evolution and it plays a key role in the regulation of cell division. The encoded protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2 (CDK1) and triggers entry into mitosis. Also, it is thought to suppress p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of them is not known.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Dual specificity phosphatase Cdc25C; EC 3.1.3.48; M-phase inducer phosphatase 3; mitosis inducer CDC25; MPIP3; OTTHUMP00000159490; OTTHUMP00000224012; OTTHUMP00000224013; OTTHUMP00000224016; phosphotyrosine phosphatase; protein phosphatase 1, regulatory subunit 60
基因别名: CDC25; CDC25C; PPP1R60
UniProt ID: (Human) P30307
Entrez Gene ID: (Human) 995, (Rat) 307511
regulation of cyclin-dependent protein serine/threonine kinase activity
G2/M transition of mitotic cell cycle
DNA replication
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
mitotic nuclear division
regulation of mitotic nuclear division
spermatogenesis
cell proliferation
viral process
peptidyl-tyrosine dephosphorylation
cell division
regulation of cell cycle
