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Invitrogen
Cdc37 Polyclonal Antibody
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Cdc37 Antibody (PA1-29131) in WB
Western blot analysis was performed on whole cell extracts (30 µg lysate) of NIH/3T3 (Lane 1), Neuro 2a (Lane 2), A549 (Lane 3) and PC-12 (Lane 4). The blot was probed with Anti-Cdc37 Polyclonal Antibody (Product # PA1-29131, 1 µg/mL) and detected by chemiluminescence using Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, HRP conjugate (Product # A27036, 0.25 µg/mL, 1:4000 dilution). A 50 kDa band corresponding to CDC37 was observed across the cell lines tested.
产品信息
PA1-29131
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to residues 369-379 (Cys-PKAGNEKDVSA) from the C-terminus of MOUSE Cdc37
偶联物
形式
Liquid
浓度
1 mg/mL
保存条件
4°C, do not freeze
运输条件
Wet ice
RRID
产品详细信息
PA1-29131 detects CDC37 from human and mouse samples.
PA1-29131 has been successfully used in immunoprecipitation and Western blot applications.
The PA1-29131 immunogen is: Synthetic peptide corresponding to residues 369-379 (Cys-PKAGNEKDVSA) from the C-terminus of MOUSE Cdc37
靶标信息
In S. cerevisiae, Cdc37 has been shown to be an important regulator of cell division cycle through its action on cyclin-dependent kinases (CDK's). Cdc37 has also been associated with signaling pathways and kinases unrelated to cell cycle control, including v-Src, casein kinase II, MPS1 kinase and the sevenless receptor tyrosine kinase. Interestingly, HSP90 has also been shown to be associated with many of the same cellular targets as Cdc37. It has now been shown that Cdc37 is the same protein previously described as p50 which has been found to be associated with many of the same proteins as HSP90. Among others, Cdc37/p50 has been found complexed with Src-family kinases (Fyn, Yes, Fes, Lck & Fgr), Raf and pp60v-src. More recently, Cdc37 has been shown to be a chaperone independently and in concert with HSP90. In fact, Cdc37 is necessary for the binding of HSP90 to Cdk4.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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