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Chromogranin A Antibody (HA600016) in IHC (P)
Immunohistochemical analysis of paraffin-embedded human medullary thyroid carcinoma tissue using anti-Chromogranin A antibody. The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 8.0-8.4) for 20 minutes. The tissues were blocked in 5% BSA for 30 minutes at room temperature, washed with ddH2O and PBS, and then probed with the primary antibody (HA600016, 1:400) for 30 m... View More
产品信息
HA600016
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG
分类
Monoclonal
类型
Antibody
克隆号
A3H1
抗原
Recombinant protein within human Chromogranin A aa 358-457.
偶联物
Unconjugated
形式
Liquid
浓度
2 mg/mL
纯化类型
Protein G
保存液
TBS, pH 7.4, with 0.05% BSA, 40% glycerol
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
靶标信息
Chromogranin A (CHGA) is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocine cells. CHGA is a precursor to three biologically active peptides: vasostatin, pancreastatin, and parastatin. These peptides act as autocine or paracrine negative modulators of the neuroendocrine system. CHGA is an excellent marker for carcinoid tumors, pheo-chromocytomas, paragangliomas, and other neuro-endocrine tumors. Coexpression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: betagranin (N-terminal fragment of chromogranin A); catestatin; CgA; chromofungin; Chromogranin-A; CTNNB; DKFZp686D02253; FLJ25606; FLJ37923; MGC105435; parathyroid secretory protein 1; Pituitary secretory protein I; SP-I
基因别名: CGA; CHGA; ChrA
UniProt ID: (Human) P10645, (Mouse) P26339
Entrez Gene ID: (Human) 1113, (Rat) 24258, (Mouse) 12652
regulation of the force of heart contraction
organelle organization
positive regulation of cAMP metabolic process
ovulation cycle
negative regulation of vasodilation
positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway
negative regulation of neuron death
mast cell chemotaxis
regulation of blood pressure
killing of cells of other organism
mast cell cytokine production
negative regulation of catecholamine secretion
mast cell degranulation
innate immune response
mast cell activation
defense response to Gram-negative bacterium
defense response to Gram-positive bacterium
defense response to fungus
positive regulation of cardiac muscle contraction
adrenergic receptor signaling pathway involved in cardiac muscle relaxation
positive regulation of relaxation of cardiac muscle
positive regulation of dense core granule biogenesis
