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Invitrogen
Cibisatamab Humanized Recombinant Human Monoclonal Antibody
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产品信息
MA5-42186
产品规格
种属反应
Human
宿主/亚型
Human
/ IgG1, kappa/IgG1, lambda
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
抗原
Human CD3E/CEACAM5
偶联物
形式
Liquid
浓度
2.54 mg/mL
纯化类型
Protein A/G
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Endotoxin level < 0.01EU/µg by LAL method
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 °C for one week. Store at -20 to -80 °C for twelve months from the date of receipt.
靶标信息
Cibisatamab (CEA-TCB) is a T cell bispecific antibody that binds carcinoembryonic antigen (CEA) on cancer cells and CD3 on T cells. Cibisatamab has a single CD3epsilon chain binding site and two CEA binding sites on T cells (it regulates the binding affinity to cancer cells with high expression of CEA on the cell surface). This avoids targeting healthy epithelial cells with low CEA expression levels. T cell activation, cytokine secretion and release of cytotoxic particles are triggered by binding to CEA on the surface of cancer cells and CD3 on T cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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