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Specificity: cingulin (a 150 kD polypeptide) present in tight junctions (zonula occludens) of polar epithelia (e.g. colon, duodenum, kidney, liver, pancreas), of transitional epithelia (e.g. bladder epithelium), and of stratified epithelia (e.g. skin, foot sole, tongue, oesophagus, vagina).Negative with endothelia of vessels and capillaries (e.g. in heart and brain). Polypeptide reacting: Cingulin, 126.5 kD polypeptide (calculated from aa sequence data); apparent MW 150 kD (after SDS-PAGE); pI 6.5 (very similar to symplekin, another junctional protein).Reactivity on cultured cell lines: Carcinoma cell lines (e.g. MCF-7, Caco-2, PLC, A-431), SV80 (fibroblasts), Glioma; MDBK, MDCK, BMGE.
Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Cingulin
基因别名: 6330408J11Rik; CGN; KIAA1319
UniProt ID: (Human) Q9P2M7
Entrez Gene ID: (Human) 57530, (Bovine) 533725, (Mouse) 70737