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Invitrogen
Claudin 3 Polyclonal Antibody
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Claudin 3 Antibody (34-1700) in ICC/IF
Immunofluorescence analysis of Claudin-3 was performed using 70% confluent log phase NIH:OVCAR-3 cells. The cells were fixed with 4% paraformaldehyde for 5 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 2% BSA for 45 minutes at room temperature. The cells were labeled with Claudin 3 Polyclonal Antibody (Product # 34-1700) at 1:100 dilution in 0.1% BSA, incubated at 4 degree ... View More
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.jpg?time=20220826?time=20220826 "Claudin 3 Antibody (34-1700) in IHC")
.jpg?time=20220826?time=20220826 "Claudin 3 Antibody (34-1700) in WB, IHC")
.jpg?time=20220826?time=20220826 "Claudin 3 Antibody (34-1700) in WB, IHC")
产品信息
34-1700
应用
建议稀释比
已发表文章
产品规格
种属反应
Dog,
Human,
Mouse
已发表种属
Amphibian,
Bovine,
C. elegans,
Dog,
Fish,
Goat,
Hamster,
Human,
Mouse,
Pig,
Plant,
Rabbit,
Rat,
Rhesus monkey,
Sheep,
Virus,
Xenopus,
Zebrafish
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide derived from the C-terminal region of mouse Claudin-3
偶联物
形式
Liquid
浓度
0.25 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4
内含物
0.1% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody is specific for the 22 kDa Claudin-3 protein. Reactivity has been confirmed with mouse liver and lung homogenates, canine MDCK and human MCF-7 cell lysates by western blotting, and with formalin-fixed, paraffin-embedded (FFPE) human normal colon and colon cancer tissues by immunohistochemistry. For best results in immunohistochemistry with formalin-fixed, paraffin-embedded (FFPE) tissues, heat induced epitope retrieval (HIER) with citrate buffer, pH 6.0, is required prior to staining.
靶标信息
Claudin 1-8 proteins are a family of transmembrane proteins associated with tight junctions. Tight junctions are specialized regions of cell to cell contact; made up of network of strands to act as a molecular gasket for preventing the leakage of ions, water etc. between cells. They are abundant in luminal epithelial sheets where they maintain epithelial cell polarity. Different tissues exhibit different Claudin composition. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc. Alternatively spliced transcript variants encoding different isoforms have been found.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Claudin-3; Clostridium perfringens enterotoxin receptor 2; CPE-R 2; CPE-receptor 2; hRVP1; integral membrane protein claudin-3; Rat ventral prostate.1 protein homolog; ventral prostate.1 protein homolog; ventral prostate.1-like protein
基因别名: AI182374; C7orf1; CLDN3; CPE-R2; CPETR2; HRVP1; mRVP1; RVP1
UniProt ID: (Human) O15551, (Dog) Q95KM5, (Mouse) Q9Z0G9
Entrez Gene ID: (Human) 1365, (Dog) 403648, (Mouse) 12739
response to hypoxia
epithelial cell morphogenesis
signal transduction
calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
protein homooligomerization
protein heterooligomerization
bicellular tight junction assembly
positive regulation of protein phosphorylation
negative regulation of cell proliferation
positive regulation of gene expression
negative regulation of gene expression
establishment of endothelial blood-brain barrier
regulation of cell morphogenesis
positive regulation of cell migration
negative regulation of cell migration
actin cytoskeleton reorganization
cell junction maintenance
negative regulation of wound healing
positive regulation of wound healing
regulation of membrane permeability
positive regulation of bicellular tight junction assembly
positive regulation of metallopeptidase activity
