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Invitrogen
Claudin 4 Polyclonal Antibody (ZMD.306)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
.jpg?time=20220826?time=20220826 "Claudin 4 Antibody (36-4800) in IHC")
.jpg?time=20220826?time=20220826 "Claudin 4 Antibody (36-4800) in IHC")
.jpg?time=20220826?time=20220826 "Claudin 4 Antibody (36-4800) in IHC")
产品信息
36-4800
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse,
Rat
已发表种属
Dog,
Hamster,
Human,
Mouse,
Non-human primate,
Pig,
Plant,
Rat,
Sheep,
Xenopus
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
克隆号
ZMD.306
抗原
Synthetic peptide derived from the C-terminal region of mouse Claudin-4
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.25 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4
内含物
0.1% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reactivity has been confirmed with mouse and rat kidney homogenates. On western blots a 22 kDa band is observed and a 44 kDa band representing dimerized protein may be observed.
靶标信息
Claudin-4 belongs to the 20-member family of claudins, transmembrane cellular adhesion proteins localized at epithelial and endothelial tight junctions. Claudins demonstrate distinct, tissue-specific expression patterns, and are essential components of tight junction charge-specific channels that regulate paracellular ion flux. Claudin-4 is a component of tight junction strands and may play a role in internal organ development and function during pre- and postnatal life. The overexpression of Claudin-4 has been shown to decrease paracellular electrical conductance due to a selective decrease in Na+ permeability, with no significant decrease in Cl- permeability. In ovarian carcinoma cells, Claudin-3 and Claudin-4 exhibit upregulation at both mRNA and protein levels. Claudin-4 is also overexpressed in pancreatic cancer tissues and cell lines, and in other epithelial cancers. The Claudin-4 gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Claudin-4; CLAUDIN4; Clostridium perfringens enterotoxin receptor; CPE-R; CPE-receptor; h CPE-receptor
基因别名: Cep-r; Cldn4; Cper; Cpetr; Cpetr1
UniProt ID: (Mouse) O35054
Entrez Gene ID: (Rat) 304407, (Mouse) 12740
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