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FIGURE: 1 / 1
Claudin 7 Antibody (PA5-96042) in WB
Western blot analysis of Claudin 7 in extracts of various cell lines. Samples were incubated with Claudin 7 Polyclonal antibody (Product # PA5-96042) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.
Product Details
PA5-96042
产品规格
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 29-211 of human CLDN7.
Conjugate
Unconjugated
形式
Liquid
浓度
0.73 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
RRID
AB_2807844
Product Specific Information
Immunogen sequence: QWQMSSYAGD NIITAQAMYK GLWMDCVTQS TGMMSCKMYD SVLALSAALQ ATRALMVVSL VLGFLAMFVA TMGMKCTRCG GDDKVKKARI AMGGGIIFIV AGLAALVACS WYGHQIVTDF YNPLIPTNIK YEFGPAIFIG WAGSALVILG GALLSCSCPG NESKAGYRVP RSYPKSNSSK EYV; Positive Samples: MCF7, HT-29, A-549, HO-8910PM, Mouse lung, Mouse kidney, Mouse liver, rat kidney, rat liver; Cellular Location: Cell junction, Cell membrane, Lateral cell membrane, Multi-pass membrane protein, tight junction
Target Information
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc. Alternatively spliced transcript variants encoding different isoforms have been found.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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Bioinformatics
Protein Aliases: Claudin-7; CLDN-7; clostridium perfringens enterotoxin receptor-like 2
Gene Aliases: CEPTRL2; claudin-1; CLDN-7; CLDN7; CPETRL2; Hs.84359
UniProt ID: (Human) O95471, (Rat) Q9Z1L1, (Mouse) Q9Z261
Entrez Gene ID: (Human) 1366, (Rat) 65132, (Mouse) 53624
Molecular Function:
tight junction
positive regulation of defense response to virus by host
negative regulation of cell adhesion
positive regulation of cell proliferation
calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
negative regulation of protein homooligomerization
negative regulation of apoptotic process
xenophagy
positive regulation of cell motility
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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