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Invitrogen
Clostridium tetani Tetanus Toxin Polyclonal Antibody
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产品信息
PA1-73168
产品规格
种属反应
Bacteria
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Purified tetanus toxoid.
偶联物
形式
Liquid
浓度
5 mg/mL
纯化类型
IgG fraction
保存液
PBS, pH 7.2
内含物
0.1% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
The PA1-73168 antibody reacts with Tetanus toxoid.
Potential applications for PA1-73168 are numerous including ELISA, Western blot, Immunofluorescence and Immunohistochemical applications. In addition this product may be used in place of neat antiserum in almost any appropriate antibody-based technique.
The PA1-73168 antibody was raised against purified tetanus toxoid.
靶标信息
Tetanus toxin is a neurotoxin produced by the vegetative spore of Clostridium tetani. The toxin causes tetanus, a disease that is characterised by prolonged contraction of skeletal muscle. World-wide, approximately 1 million cases of tetanus occurs annually, resulting in approximately 300,000 to 500,000 deaths, mostly in developing countries. The tetanus toxin has a molecular weight of approximately 150kDa and consists of a heavy chain (B-chain, 100kDa) and a light chain (A-chain, 50kDa) that are connected by a disulfide bond. The toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits the release of the neurotransmitters GABA and glycine by synaptobrevin-2. This results in overactivity in the muscle. The binding of the toxin to neurons is irreversible.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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