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Invitrogen
Collagen I Polyclonal Antibody
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产品信息
PA1-27397
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Collagen type I purified from rat skin
偶联物
形式
Liquid
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
产品详细信息
PA1-27397 detects Collagen I from rat samples. PA1-27397 will not react with Collagen type I from human or chicken sources, or with mouse Collagen type I when tested by RIA. It is also known that this antibody is not reactive with rat Collagen type III or Elastin. Cross-reacts with mouse collagen type 1 when tested by ELISA and IHC but does not cross react when tested by RIA.
PA1-27397 has been successfully used in immunofluorescence, ELISA and radioimmune assay procedures.
The PA1-27397 immunogen is Collagen type I purified from rat skin.
Store at 4°C short term. For extended storage aliquot and store at -20°C or below. Avoid freeze/thaw cycles.
靶标信息
Collagen I is a Type I collagen with a triple helix structure comprised of two alpha-1 chains and one alpha-2 chain. Collagen I is a member of group I collagen (fibril-forming collagen) found in most connective tissues, and is abundant in bone, cornea, dermis and tendon. Mutations in the COL1A2 gene encoding the alpha-2 chain are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in the COL1A2 gene which codes for the alpha-2 chain, however, tend to be less severe than mutations in the COL1A1 gene, reflecting the different role of alpha-2 chains in matrix integrity. Reciprocal translocations between chromosomes 17 and 22, where Collagen Type 1 genes and the gene for platelet derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
