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Invitrogen
Collagen I Monoclonal Antibody (COL-1)
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Collagen I Antibody (MA1-26771) in IHC (P)
Collagen I Monoclonal Antibody (COL-1) detects Collagen I protein at cell membrane by immunohistochemical analysis. Sample: Paraffin-embedded rabbit tongue. Collagen I stained by Collagen I Monoclonal Antibody (COL-1) (Product # MA1-26771) diluted at 1:200. Antigen Retrieval: Citrate buffer, pH 6.0, 15 min.
产品信息
MA1-26771
应用
建议稀释比
已发表文章
产品规格
种属反应
Bovine,
Deer,
Human,
Mouse,
Pig,
Rabbit,
Rat
已发表种属
C. elegans,
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
COL-1
抗原
Bovine skin collagen type I.
偶联物
形式
Liquid
浓度
6.4 mg/mL
保存液
ascites
内含物
15mM sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
The antibody is reactive with the native (helical) form of collagen type I in ELISA and dot blot. The product is not reactive when tested on thermally denatured molecules. In immunohistochemical staining of acetone-fixed and unfixed frozen sections, a strong staining of connective tissue fibers is seen. Using the dot blot and ELISA techniques, the antibody shows no cross-reactivity with collagen types, II, III, IV, V, VI, VII, IX, X and XI. The epitope recognized by the antibody is sensitive to routine formalin fixation and paraffin embedding.|Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
Collagen I is a Type I collagen with a triple helix structure comprised of two alpha-1 chains and one alpha-2 chain. Collagen I is a member of group I collagen (fibril-forming collagen) found in most connective tissues, and is abundant in bone, cornea, dermis and tendon. Mutations in the COL1A2 gene encoding the alpha-2 chain are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in the COL1A2 gene which codes for the alpha-2 chain, however, tend to be less severe than mutations in the COL1A1 gene, reflecting the different role of alpha-2 chains in matrix integrity. Reciprocal translocations between chromosomes 17 and 22, where Collagen Type 1 genes and the gene for platelet derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: alpha 1 type I collagen; alpha 2 type I procollagen; alpha 2(I) procollagen; alpha 2(I)-collagen; alpha-1 type 1 collagen; Alpha-1 type I collagen; Alpha-2 type I collagen; alpha1 chain of type I collagen; alpha1(I) procollagen; alpha2 chain of type I collagen; COL1; COL1A1; COL1A1; matrix protein; collagen 1 alpha 2 chain; collagen alpha 1 chain type I; Collagen alpha-1(I) chain; collagen alpha-1(I) chain preproprotein; Collagen alpha-2(I) chain; collagen COL1A2; collagen I alpha-2 polypeptide; collagen I, alpha-2 polypeptide; collagen of skin, tendon and bone, alpha-1 chain; collagen of skin, tendon and bone, alpha-2 chain; collagen type I alpha 1; collagen, type 1, alpha 1; collagen, type I, alpha 1; collagen, type I, alpha 2; osteogenesis imperfecta; prepro-alpha-1 collagen type I; pro-alpha-1 collagen type 1; procollagen type I, alpha 1; procollagen, type 1, alpha 1; procollagen, type I, alpha 1; procollagen, type I, alpha 2; Type I Collagen; type I proalpha 1; type I procollagen; type I procollagen alpha 1 chain; type I-alpha 1 collagen
基因别名: AA960264; AI325291; Col1a-1; Col1a-2; COL1A1; COL1A2; Cola-1; Cola-2; Cola1; Cola2; COLIA1; EDSC; Mov-13; Mov13; OI1; OI2; OI3; OI4; oim
skeletal system development
blood vessel development
osteoblast differentiation
intramembranous ossification
endochondral ossification
blood coagulation
visual perception
sensory perception of sound
positive regulation of epithelial to mesenchymal transition
negative regulation of cell-substrate adhesion
protein transport
platelet activation
extracellular matrix organization
collagen fibril organization
positive regulation of cell migration
collagen catabolic process
response to corticosteroid
response to estradiol
collagen biosynthetic process
protein localization to nucleus
tooth mineralization
response to drug
response to hydrogen peroxide
response to peptide hormone
skin morphogenesis
cellular response to fibroblast growth factor stimulus
tooth eruption
positive regulation of transcription, DNA-templated
embryonic skeletal system development
regulation of immune response
leukocyte migration
response to cAMP
response to hyperoxia
face morphogenesis
bone trabecula formation
cartilage development involved in endochondral bone morphogenesis
protein heterotrimerization
cellular response to amino acid stimulus
cellular response to mechanical stimulus
cellular response to retinoic acid
cellular response to vitamin E
cellular response to tumor necrosis factor
cellular response to epidermal growth factor stimulus
cellular response to transforming growth factor beta stimulus
positive regulation of canonical Wnt signaling pathway
cellular response to fluoride
transforming growth factor beta receptor signaling pathway
Rho protein signal transduction
regulation of blood pressure
odontogenesis
bone mineralization
collagen metabolic process
extracellular matrix assembly
ossification
response to nutrient
response to mechanical stimulus
response to nutrient levels
wound healing
skin development
response to steroid hormone
skeletal system morphogenesis
response to fluoride
cellular response to organic substance
response to norepinephrine
cellular response to thyroid hormone stimulus
