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Invitrogen
Collagen II Polyclonal Antibody
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Collagen II Antibody (PA5-99159) in IHC (P)
Immunohistochemistry analysis of Collagen II in human lung cancer. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with Collagen II polyclonal antibody (Product # PA5-99159) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-99159
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human COL2A1(Accession P02458), corresponding to amino acid residues K113-P163.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total Collagen II.
靶标信息
COL2A1 is the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Alpha-1 type II collagen; arthroophthalmopathy, progressive (Stickler syndrome); cartilage collagen; CGA; chondrocalcin; COL2A1; Collagen 2; Collagen alpha-1(II) chain; collagen II, alpha-1 polypeptide; collagen type II (Col2A1) gene, enhancer region; collagen, type II, alpha 1; disproportionate micromelia; MGC131516; Procollagen II alpha 1; procollagen, type II, alpha 1; unnamed protein product
基因别名: ACG2; ANFH; ANFH1; AOM; CG2A1A; COL11A3; Col2; Col2a; Col2a-1; COL2A1; COLLII; Del1; Dmm; EDMMD; LCPD; Lpk; M100856; OSCDP; PLSDT; Rgsc856; SEDC; SEDSTN; SEMDSTWK; SMDALG; STL1; VPED
UniProt ID: (Rat) P05539, (Mouse) P28481
Entrez Gene ID: (Human) 1280, (Rat) 25412, (Mouse) 12824
extracellular matrix structural constituent
protein binding
extracellular matrix structural constituent conferring tensile strength
MHC class II protein binding
identical protein binding
protein homodimerization activity
proteoglycan binding
platelet-derived growth factor binding
metal ion binding
extracellular matrix structural protein
skeletal system development
ossification
chondrocyte differentiation
central nervous system development
visual perception
sensory perception of sound
collagen fibril organization
notochord development
animal organ development
skeletal system morphogenesis
system development
cartilage development
limb bud formation
embryonic skeletal joint morphogenesis
otic vesicle development
cartilage condensation
tissue homeostasis
endochondral ossification
heart morphogenesis
growth plate cartilage development
proteoglycan metabolic process
response to mechanical stimulus
response to X-ray
regulation of gene expression
limb morphogenesis
inner ear morphogenesis
inner ear development
palate development
bone development
cartilage development involved in endochondral bone morphogenesis
cellular response to mechanical stimulus
cellular response to retinoic acid
cellular response to vitamin E
cellular response to nicotine
cellular response to tumor necrosis factor
cellular response to parathyroid hormone stimulus
cellular response to peptide hormone stimulus
cellular response to BMP stimulus
response to fibroblast growth factor
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
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