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For immunohistochemistry on paraffin tissue the sections should be pretreated with 1 mg/mL pepsin in 0.01 N HCl for 30 minutes at room temperature.
The antibody may be stored at 4°C. For prolonged storage prepare appropriate aliquots and store at or below -20°C. Prior to use, an aliquot is thawed slowly in the dark at ambient temperature, spun down again and used to prepare working dilutions by adding sterile phosphate buffered saline (PBS, pH 7.2). Repeated thawing and freezing should be avoided. Working dilutions should be stored at 4°C, not refrozen, and preferably used the same day. If a slight precipitation occurs upon storage, this should be removed by centrifugation. It will not affect the performance or the concentration of the product.
Collagen IV is a type of collagen protein that is a major component of the basement membrane in various tissues, including the kidneys, lungs, and skin. It forms a network-like structure that provides support and stability to the surrounding tissue. Collagen IV is composed of three alpha chains, which are encoded by the COL4A1, COL4A2, and COL4A3 genes. Mutations in these genes can lead to various genetic disorders, such as Alport syndrome and Goodpasture syndrome, which affect the kidneys and lungs, respectively.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: a matrix-derived inhibitor of angiogenesis and tumor growth; a3(IV)NC1; alpha 1 type IV collagen; alpha-2 collagen type IV; alpha-3 type IV collagen; arresten; canstatin; COL4A1 NC1 domain; COL4A2 NC1 domain; COL4A3 NC1 domain; Collagen 4; Collagen alpha-1(IV) chain; collagen alpha-2 type IV; Collagen alpha-2(IV) chain; Collagen alpha-3(IV) chain; Collagen alpha-4(IV) chain; Collagen alpha-5(IV) chain; Collagen alpha-6(IV) chain; collagen IV, alpha-1 polypeptide; collagen IV, alpha-3 polypeptide; Collagen IV, alpha-4 polypeptide; collagen IV, alpha-5 polypeptide; collagen IV, alpha-6 polypeptide; collagen of basement membrane, alpha-1 chain; collagen of basement membrane, alpha-4 chain; collagen of basement membrane, alpha-5 chain; collagen of basement membrane, alpha-6; collagen type IV alpha 5 chain; collagen, type IV, alpha 1; collagen, type IV, alpha 2; collagen, type IV, alpha 3 (Goodpasture antigen); collagen, type IV, alpha 4; collagen, type IV, alpha 5; collagen, type IV, alpha 6; contains COL4A1 NC1 domain; dA149D17.3; dA24A23.1; dJ889N15.4 (Collagen Alpha 6(IV)); Goodpasture antigen; matrix-derived inhibitor of angiogenesis and tumor growth; non-collagenous 1 domain from alpha 1 chain of type IV collagen; pro-alpha-1(IV); procollagen alpha-1 type IV; procollagen, type IV, alpha 1; procollagen, type IV, alpha 2; procollagen, type IV, alpha 3; procollagen, type IV, alpha 4; procollagen, type IV, alpha 5; soluble Col4A1 protein; structural non-collagenous NC1 domain; a6[IV]NC1; tumstatin; Type IV Collagen; unnamed protein product
基因别名: ASLN; ATS; ATS1; ATS2; ATS3; ATS3A; ATS3B; BFH; BFH1; BFH2; BSVD; BSVD1; BSVD2; CA44; CA54; COL4A1; COL4A1s; COL4A2; COL4A3; COL4A4; COL4A5; COL4A6; CXDELq22.3; DELXq22.3; DFNX6; ICH; PADMAL; POREN2; RATOR; RGD1565499
UniProt ID: (Bovine) Q7SIB2, (Human) P02462, (Human) P08572, (Human) Q01955, (Human) P53420, (Human) P29400, (Human) Q14031
Entrez Gene ID: (Pig) 100515336, (Bovine) 282191, (Human) 1282, (Pig) 100153454, (Human) 1284, (Bovine) 317711, (Pig) 100621504, (Human) 1285, (Bovine) 407107, (Pig) 100621403, (Human) 1286, (Human) 1287, (Pig) 100737091, (Human) 1288, (Pig) 100620724, (Rat) 290905, (Rat) 306628, (Rat) 363265, (Rat) 301562, (Rat) 363457, (Rat) 363458