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Proteintech
Collagen Type XXV Polyclonal Antibody
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产品信息
12738-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Collagen Type XXV fusion protein Ag3634
偶联物
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
产品详细信息
Immunogen sequence: GPLGPPGQKG SIGAPGIPGM NGQKGEPGLP GAVGQNGIPG PKGEPGEQGE KGDAGENGPK GDTGEKGDPG SSAAGIKGEP GESGRPGQKG EPGLPGLPGL PGIKGEPGFI GPQGEPGLPG LPGTKGERGE AGPPGRGERG EPGAPGPKGK QGESGTRGPK GSKGDRGEKG DSGAQGPRGP PGQKGDQGAT EIIDYNGNLH EALQRITTLT VTGPPGPPGP QGLQGTKGEQ GSPGIPGMDG EQGLKGSKGD MGDPGSQWNE RRKRRFWNAG STGSFYHRPT RPTRSPWPTW PHGTSWTSWT KGSIWLRRKA RIPGYRWSYG TPWPCRSQRR KR
靶标信息
Alzheimer's disease (AD) is characterized by deposition of beta-amyloid as senile plaques and cerebral amyloid angiopathy. The principal component of AD amyloid is the amyloid beta peptide (A beta). Although production and deposition of A beta appear closely related to the pathogenesis of AD, current evidence suggest that A beta alone is not sufficient to cause neuronal death and symptoms of dementia. A component of senile plaque (SP), CLAC (collagen-like Alzheimer amyloid plaque component ) and its precursor CLAC-P are deposited with extracellular beta-amyloid and have been recently implicated in cell toxicity of beta-amyloid in AD brains. CLAC-P is a unique, membrane-bound collagen-like structure containing three Gly-X-Y repeat motifs and may define a novel class of neuronal collagens.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Alzheimer disease amyloid-associated protein; AMY; CLAC-P; col25a1; Collagen alpha-1(XXV) chain; collagen, type XXV, alpha 1; collagen-like Alzheimer amyloid plaque component; collagenous Alzheimer amyloid plaque component; procollagen, type XXV, alpha 1
基因别名: 2700062B08Rik; AMY; CFEOM5; CLAC; CLAC-P; CLACP; COL25A1
UniProt ID: (Human) Q9BXS0, (Mouse) Q99MQ5
Entrez Gene ID: (Human) 84570, (Rat) 687064, (Mouse) 77018
