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This antibody does not react with bovine, cat, dog, guinea pig, mouse, rabbit, rat or sheep.
It has been reported that this antibody works very well on acetone-fixed, frozen renal biopsies. Strong staining is observed in the glomeruli and in some cases the peritubular capillaries. Clone 10-11 has given variable results on formalin-fixed, paraffin-embedded sections. It has been observed that pre-treatment with 88% formic acid for 20 minutes at room temperature is beneficial.
Mouse anti Human C4d antibody, clone 10-11 recognizes the secreted protein complement component 4d (C4d).
C4 is a component of the classical complement pathway and is split by activated C1s to C4a and C4b. Together C2a and C4b forms the classical C3 convertase. The molecular mass of C4 is 204 kDa and it consists of 3 subunits: a (97 kDa), b (75 kDa) and g (33 kDa).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: acidic C4; Acidic complement C4; Basic complement C4; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3; c4 complement; C4A anaphylatoxin; C4D; Chido form of C4; Complement C4-A; Complement C4-B; complement C4B1a; DADB-112B14.11; FLJ60561; MGC164979; MHC class III region complement; Rodgers form of C4
基因别名: C4; C4A; C4A2; C4A3; C4A4; C4A6; C4AD; C4B; C4B1; C4B12; C4B2; C4B3; C4B5; C4B_2; C4BD; C4F; C4S; CH; CO4; CPAMD2; CPAMD3; RG
UniProt ID: (Human) P0C0L4, (Human) P0C0L5, (Human) Q6VCV8
Entrez Gene ID: (Human) 720, (Human) 721, (Human) 100293534
分子生物学功能: protease inhibitor