Invitrogen

Connexin 40 Polyclonal Antibody

查看其他6个Connexin 40抗体

问题与答案

问题与答案

问题与答案

Immunogen image

Connexin 40 Polyclonal Antibody

Immunogen Image Connexin 40 Polyclonal Antibody

产品信息

PA1-18406

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:10,000-1:50,000

-

产品规格

种属反应

Rat

宿主/亚型

Sheep / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide corresponding to residues S(253) L V Q G L T P P P D F N Q C L K(269) of rat Connexin-40.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

Conc. Not Determined

保存液

whole serum

内含物

no preservative

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20 °C for a higher stability, and at 4 °C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.

靶标信息

Connexin 40 (Cx40), belongs to the connexin family of gap junction proteins, which are expressed in pancreas, kidney, skeletal muscle, liver, placenta and heart. Connexin 40 is highly expressed in vascular endothelial cells, and the mammalian heart (specifically in the atrial myocardium, and the His-Purkinje conduction system). At least three other connexins are expressed in the heart, including Cx37 (endocardium), Cx43 (atrial and ventricular myocardium, and distal parts of the conduction system) and Cx45 (throughout the heart). Cx40 and Cx43 frequently co-localize in cells of the cardiovascular system and participate in the formation of heterotypic gap junction channels.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: connexin 40; Connexin-40; Cx40; Gap junction alpha-5 protein; gap junction membrane channel protein alpha 5

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基因别名: Cx40; Cxn-40; Gja5

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UniProt ID: (Rat) P28234

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Entrez Gene ID: (Rat) 50563

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gap junction channel activity gap junction hemi-channel activity connexin binding gap junction channel activity involved in cardiac conduction electrical coupling gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling gap junction

skeletal system development angiogenesis blood vessel development renal system process involved in regulation of systemic arterial blood pressure regulation of systemic arterial blood pressure negative regulation of glomerular filtration outflow tract morphogenesis endothelium development cardiac conduction system development mitral valve development pulmonary valve formation ventricular septum development atrial septum development septum primum development atrial ventricular junction remodeling potassium ion transport heart development cell communication by chemical coupling cell communication by electrical coupling positive regulation of cell communication by chemical coupling gap junction assembly embryonic limb morphogenesis embryonic heart tube development foramen ovale closure regulation of vasodilation negative regulation of blood pressure positive regulation of vasoconstriction positive regulation of vasodilation artery morphogenesis protein oligomerization transmembrane transport regulation of cardiac muscle contraction regulation of ventricular cardiac muscle cell membrane repolarization regulation of atrial cardiac muscle cell membrane depolarization regulation of ventricular cardiac muscle cell membrane depolarization ventricular septum morphogenesis atrial septum morphogenesis cardiac conduction ventricular cardiac muscle cell action potential atrial cardiac muscle cell action potential SA node cell action potential AV node cell to bundle of His cell communication by electrical coupling cell communication by electrical coupling involved in cardiac conduction cell communication involved in cardiac conduction AV node cell to bundle of His cell communication bundle of His cell to Purkinje myocyte communication regulation of heart rate by cardiac conduction regulation of renin secretion into blood stream regulation of membrane depolarization during cardiac muscle cell action potential vasomotion