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| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
免疫印迹 (WB) |
2 µg/mL | - |
免疫细胞化学 (ICC/IF) |
1:1,000 | - |
| 产品规格 | |
|---|---|
种属反应 |
Human, Mouse |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
A synthetic peptide made to an N-terminal portion of the murine cripto protein sequence (between residues 1-50). |
偶联物 |
DyLight™ 650 |
形式 |
Liquid |
浓度 |
0.94 mg/mL |
纯化类型 |
Antigen affinity chromatography |
保存液 |
sodium borate |
内含物 |
no preservative |
保存条件 |
4° C, store in dark |
RRID |
AB_11155814 |
In Western blot a band is seen at ~18 kDa representing the core form of Cripto1, and at ~36 kDa reporesenting the glycosylated/ post-translationally modified form.
Suggested positive control: MDA-MB231 (human breast cancer) lysates.
Cripto (TDGF1) is a GPI-anchored cell membrane proetin involved in Nodal signaling. Cell associated TDGF1 acts as a a Nodeal coreceptor in cis. Shedding of TDGF1 by TMEM8A modulated Nodal signaling by allowing soluble TDGF1 to act as a Nodal coreceptor on other cells. TDGF1 is expressed both in ES cells and during the early phases of embryo development, while in adults it is reactivated in a wide range of epithelial cancers.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: CRGF; cripto growth factor; Cripto-1; Cripto-1 growth factor; Cripto-3; epidermal growth factor-like Cripto protein; Epidermal growth factor-like cripto protein CR1; TDGF2; teratocarcinoma-derived growth factor; Teratocarcinoma-derived growth factor 1; TERATOCARCINOMA-DERIVED GROWTH FACTOR PRECURSOR (EPIDERMAL GROWTH FACTOR-LIKE CRIPTO PROTEIN) (CRIPTO GROWTH FACTOR)
基因别名: CR; CR1; CRGF; CRIPTO; TDGF1
UniProt ID: (Human) P13385
Entrez Gene ID: (Human) 6997, (Mouse) 21667
分子生物学功能:
intercellular signal molecule
