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Proteintech
Cullin 5 Polyclonal Antibody
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产品信息
31183-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Cullin 5 fusion protein Ag34620
偶联物
形式
Liquid
浓度
0.4 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
产品详细信息
Immunogen sequence: MATSNLLKNK GSLQFEDKWD FMRPIVLKLL RQESVTKQQW FDLFSDVHAV CLWDDKGPAK IHQALKEDIL EFIKQAQARV LSHQDDTALL KAYIVEWRKF FTQCDILPKP FCQLEITLMG KQGSNKKSNV EDSIVRKLML DTWNESIFSN IKNRLQDSAM KLVHAERLGE AFDSQLVIGV RESYVNLCSN PEDKLQIYRD NFEKAYLDST ERFYRTQAPS YLQQNGVQNY MKYADAKLKE EEKRALRYLE TRRECNSVEA LMECCVNALV TSFKETILAE CQGMIKRNET EKLHLMFSLM
靶标信息
CUL5 is a core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAk2. It seems to be involved poteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein and may form a cell surface vasopressin receptor.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CUL-5; Cullin-5; Cullin-5 (vasopressin-activated calcium-mobilizing receptor-1); VACM-1; Vasopressin-activated calcium-mobilizing receptor 1; vasopressin-activated calcium-mobilizing receptor protein; Vasopressin-activated calcium-mobilizing receptor-1
基因别名: 4921514I20Rik; 8430423K24Rik; AI852817; C030032G03Rik; C330021I08Rik; CUL5; VACM-1; VACM1
UniProt ID: (Human) Q93034, (Rat) Q9JJ31, (Mouse) Q9D5V5
Entrez Gene ID: (Human) 8065, (Rat) 64624, (Mouse) 75717
G1/S transition of mitotic cell cycle
cell cycle arrest
cell proliferation
negative regulation of cell proliferation
viral process
ERBB2 signaling pathway
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
calcium ion transmembrane transport
intrinsic apoptotic signaling pathway
protein polyubiquitination
ubiquitin-dependent protein catabolic process
response to osmotic stress
G-protein coupled receptor signaling pathway
protein ubiquitination
cerebral cortex radially oriented cell migration
radial glia guided migration of Purkinje cell
regulation of cytosolic calcium ion concentration
