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          Disclaimer

          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • Cyclin B1 Antibodies

          Invitrogen

          Cyclin B1 Monoclonal Antibody (V152), Alexa Fluor™ 647

          查看其他44个Cyclin B1抗体

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          说明书
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          说明书
          实验方案
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          Cite Cyclin B1 Monoclonal Antibody (V152), Alexa Fluor™ 647

          • 抗体检测数据 (1)
          Cyclin B1 Antibody in Flow Cytometry (Flow)
          Group 53 Created with Sketch.
          Cyclin B1 Antibody in Flow Cytometry (Flow)
          Group 53 Created with Sketch.

          图: 1 / 1

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          Cyclin B1 Antibody (MA562404) in Flow

          Flow cytometry (intracellular staining) of Cyclin B1 in Jurkat cells. Samples were stained with Cyclin B1 monoclonal antibody (Product # MA562404) using a dilution of 0.56 µg/mL. Separation of stained Jurkat cells (red-filled) from Jurkat cells using mouse IgG1 isotype control (MOPC-21) Alexa Fluor® 488 antibody (0.56 µg/mL, black-dashed). {{ $ctrl.currentElement.advancedVerification.fullName }} 验证信息 View more
          已发表图片由___提供 benchsci-logo
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          查看产品

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          Cyclin B1 Antibody in Flow Cytometry (Flow)

          产品信息

          MA562404

          应用
          建议稀释比
          已发表文章

          免疫组化(石蜡) (IHC (P))

          Assay-dependent
          -

          免疫细胞化学 (ICC/IF)

          Assay-dependent
          -

          流式细胞分析 (Flow)

          4 µL/100 µL whole blood or 10^6 cells
          -
          产品规格

          种属反应

          Human

          宿主/亚型

          Mouse / IgG1

          分类

          Monoclonal

          类型

          Antibody

          克隆号

          V152

          抗原

          Recombinant His-tagged hamster cyclin B1.

          偶联物

          Alexa Fluor™ 647 Alexa Fluor™ 647 Alexa Fluor™ 647
          • Alexa Fluor 488 
          • Request custom conjugation

          激发/发射光谱

          650/671 nm 查看光谱 spectra

          形式

          Liquid

          浓度

          0.1 mg/mL

          纯化类型

          Size-exclusion chromatography

          保存液

          PBS, pH 7.4, with 0.2% BSA

          内含物

          15mM sodium azide

          保存条件

          4°C, store in dark, DO NOT FREEZE!

          运输条件

          Ambient (domestic); Wet ice (international)

          靶标信息

          Cyclins bind to and regulate the activity of the Cyclin dependent protein kinases (CDKs). Cyclin B1 or CCNB1 is a regulatory protein involved in mitosis. It is essential for the control of the cell cycle at the G2/M transition. Cyclin B1 complexes with p34 (cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. Cyclin B1 is not ubiquitinated during G2/M phase, resulting in its steady accumulation during G2 phase, followed by abrupt APC dependent destruction at the end of mitosis. Destruction of Cyclin B1 is required for cell cycle progression. Cyclin B1 is overexpressed in various cancers, including breast, prostate, and non-small cell lung cancer.

          仅用于科研。不用于诊断过程。未经明确授权不得转售。

          How to use the Panel Builder

          Watch the video to learn how to use the Invitrogen Flow Cytometry Panel Builder to build your next flow cytometry panel in 5 easy steps.

          篇参考文献 (0)

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          引用该产品

          生物信息学

          蛋白别名: G2/mitotic-specific cyclin B1; G2/mitotic-specific cyclin-B1; OTTHUMP00000221981; OTTHUMP00000223023

          查看更多 收起

          基因别名: CCNB; CCNB1

          查看更多 收起

          UniProt ID: (Human) P14635

          查看更多 收起

          Entrez Gene ID: (Human) 891

          查看更多 收起

          功能
          cyclin-dependent protein serine/threonine kinase activity patched binding protein binding protein kinase binding histone kinase activity kinase activator
          参与通路
          G2/M transition of mitotic cell cycle oocyte maturation in utero embryonic development negative regulation of protein phosphorylation protein complex assembly DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest mitotic spindle organization mitotic nuclear envelope disassembly mitotic metaphase plate congression spermatogenesis response to mechanical stimulus negative regulation of gene expression anaphase-promoting complex-dependent catabolic process positive regulation of mRNA 3'-end processing positive regulation of histone phosphorylation tissue regeneration response to drug protein ubiquitination involved in ubiquitin-dependent protein catabolic process positive regulation of mitotic cell cycle response to DDT positive regulation of fibroblast proliferation digestive tract development cell division negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle regulation of cell cycle positive regulation of attachment of spindle microtubules to kinetochore ventricular cardiac muscle cell development positive regulation of cardiac muscle cell proliferation regulation of chromosome condensation cellular response to iron(III) ion cellular response to fatty acid cellular response to organic cyclic compound cellular response to hypoxia regulation of mitotic cell cycle spindle assembly checkpoint histone H3-S10 phosphorylation involved in chromosome condensation
          It has to be done as per old AB suggested Products section.
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          性能保障

          只要您发现Invitrogen抗体在实验中的表现与网站或说明书的所述内容不符,您即可享受免费退换货服务。*

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