Invitrogen

Cyclophilin C Polyclonal Antibody

Product Image Gallery

Cyclophilin C Antibody in Western Blot (WB) — Figure 3 Effect of compounds 1 , 2 , and GraL over intra and extracellular CypA, B and C levels in human T lymphocytes stimulated with Con A Cells were pre-treated with compound 1 , 2 (0.1 uM), GraL (1 muM) or CsA (0.2 uM) for 2 h and then were stimulated with Con A (50 mug/mL) for 48 h. CypA (A) , CypB (B) , and CypC (C) levels were measured by ELISA in the medium of T lymphocytes. The line represents the unstimulated cells values. The intracellular expression of CypA (D) , CypB (E) , and CypC (F) was measured by western blot in cytosolic lysates of T lymphocytes. Band intensity was normalized by beta-actin. Data are the result of average +- SEM (n = 3). The values are shown as the difference between cells treated with Con A and cells treated with compounds plus Con A, * p < 0.05, ** p < 0.01 and *** p < 0.001. Values of cells treated with Con A were compared with control cells, # p < 0.05, ## p < 0.01 and ### p < 0.001. One-way ANOVA test with Dunnet''s post hoc analysis and Student''s t-test were used for statistical analysis.

产品信息

PA5-69299

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1.0 µg/mL

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产品规格

种属反应

Mouse

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

synthetic peptide directed towards the middle region of human Cyclophilin C

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偶联物

Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Affinity chromatography

保存液

PBS with 2% sucrose

内含物

0.09% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

RRID

AB_2691318

产品详细信息

This target displays homology in the following species: Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%

靶标信息

PPIC is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. Similar to other PPIases, this protein can bind immunosuppressant cyclosporin A.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Cyclophilins A, B, and C Role in Human T Lymphocytes Upon Inflammatory Conditions.

Frontiers in immunology

Gegunde S,Alfonso A,Alvariño R,Alonso E,Botana LM

PA5-69299 was used in Western Blot to investigate the function of cyclophilins and the relationship between CypA, B, and C, their receptor, and the inflammatory process in human T lymphocytes.

Fri Jul 02 00:00:00 EDT 2021

Cyclophilins A, B, and C Role in Human T Lymphocytes Upon Inflammatory Conditions.

Frontiers in immunology

Gegunde S,Alfonso A,Alvariño R,Alonso E,Botana LM

PA5-69299 was used in Western Blot to investigate the function of cyclophilins and the relationship between CypA, B, and C, their receptor, and the inflammatory process in human T lymphocytes.

Fri Jul 02 00:00:00 EDT 2021

生物信息学

蛋白别名: Cyclophilin C; Peptidyl-prolyl cis-trans isomerase C; PPIase C; Rotamase C

基因别名: CyP-20c; Cypc; Ppic

UniProt ID: (Mouse) P30412

Entrez Gene ID: (Mouse) 19038

分子生物学功能: chaperone

功能

protein peptidyl-prolyl isomerization protein folding

参与通路

peptidyl-prolyl cis-trans isomerase activity protein binding cyclosporin A binding isomerase activity peptide binding