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MUbio
Cytokeratin 10,13/Keratin K10,K13 Monoclonal Antibody (DE-K13)
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产品信息
MUB0321P
应用
建议稀释比
已发表文章
产品规格
种属反应
Dog,
Cat,
Human,
Zebrafish
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
DE-K13
抗原
Cytokeratin 10+13 / Keratin K10+K13
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A/G
保存液
PBS
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
DE-K13 reacts with cytokeratin 10 and 13 in fixed cells and on frozen tissues, but exclusively with Cytokeratin 13 in formalin-fixed, paraffin-embedded tissues. Cytokeratin 10 is present in Keratinizing stratified epithelia and in differentiated areas of highly differentiated squamous cell carcinomas, while Cytokeratin 13 is present in non-cornified squamous epithelia, except cornea, and transitional epithelial regions, with the exception of basal cell layers of some stratified epithelia, as well as carcinomas derived from these tissues.
Cross-reactivity: Not reactive in mouse and rat.
The antibody may be stored at 4°C. For prolonged storage prepare appropriate aliquots and store at or below -20°C. Prior to use, an aliquot is thawed slowly in the dark at ambient temperature, spun down again and used to prepare working dilutions by adding sterile phosphate buffered saline (PBS, pH 7.2). Repeated thawing and freezing should be avoided. Working dilutions should be stored at 4°C, not refrozen, and preferably used the same day. If a slight precipitation occurs upon storage, this should be removed by centrifugation. It will not affect the performance or the concentration of the product.
靶标信息
Cytokeratins(CK) are intermediate filaments of epithelial cells, both in keratinizing tissue (ie. Skin) and non-keratinizing cells (ie. Mesothelial cells). Although not a traditional marker for endothelial cells, cytokeratins have also been found in some microvascular endothelial cells. Atleast 20 different CKs in the molecular range of 40-70 k Da and isoelectric points of 5-805 can be identified using two dimensional gel electrophoresis. Biochemically, most members of the CK family fall into one of two classes, type I (acidic polypeptides) and type II (basic polypeptides). At least one member of the acidic family and one member of the basic family is expressed in all epithelial cells. Monoclonal antibodies to cytokeratin proteins can be useful markers for tumor identification and classification.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CK-10; CK-13; cytokeratin 10; cytokeratin 13; Cytokeratin-10; Cytokeratin-13; epithelial keratin 10; Epithelial keratin-10; K10; K13; keratin 10 (epidermolytic hyperkeratosis; keratosis palmaris et plantaris); keratin 10, type I; keratin 13, type I; Keratin, type I cytoskeletal 10; Keratin, type I cytoskeletal 13; Keratin-10; Keratin-13
基因别名: BCIE; BIE; CK-10; CK10; CK13; EHK; K10; K13; KER10; KPP; KRT10; KRT13; WSN2
UniProt ID: (Human) P13645, (Dog) Q6EIZ0, (Human) P13646
Entrez Gene ID: (Human) 3858, (Dog) 491006, (Dog) 490983, (Human) 3860
