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MUbio
Cytokeratin 16/Keratin K16 Monoclonal Antibody (LL025)
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产品信息
MUB0351P
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
LL025
抗原
Cytokeratin 16 / Keratin K16
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A/G
保存液
PBS
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Keratin 16 is specifically found in hyperproliferative squamous epithelium such as psoriatic lesions and squamous cell carcinomas, e.g. of the lung. It is expressed in suprabasal Keratinocytes of wounded epidermis, a situation of high cell turnover. LL025 reactivity is negative in, e.g. normal skin, breast and lung tissue and non-invasive breast carcinoma. However, 10% of the invasive breast carcinomas tested were diffusely or focally positive with this antibody.
For use in paraffin embedded tissue sections high pressure retrieval at pH 8,0 is recommended.
The antibody may be stored at 4°C. For prolonged storage prepare appropriate aliquots and store at or below -20°C. Prior to use, an aliquot is thawed slowly in the dark at ambient temperature, spun down again and used to prepare working dilutions by adding sterile phosphate buffered saline (PBS, pH 7.2). Repeated thawing and freezing should be avoided. Working dilutions should be stored at 4°C, not refrozen, and preferably used the same day. If a slight precipitation occurs upon storage, this should be removed by centrifugation. It will not affect the performance or the concentration of the product.
靶标信息
KRT16 is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region of chromosome 17q12-q21. This keratin has been coexpressed with keratin 14 in a number of epithelial tissues, including esophagus, tongue, and hair follicles. Mutations in this gene are associated with type 1 pachyonychia congenita, non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CK-16; cytokeratin 16; Cytokeratin-16; focal non-epidermolytic palmoplantar keratoderma; K16; keratin 16, type I; Keratin, type I cytoskeletal 16; Keratin-16
基因别名: CK16; FNEPPK; K16; K1CP; KRT16; KRT16A; NEPPK; PC1
UniProt ID: (Human) P08779
Entrez Gene ID: (Human) 3868
morphogenesis of an epithelium
inflammatory response
cytoskeleton organization
aging
cell proliferation
epidermis development
keratinocyte differentiation
negative regulation of cell migration
keratinization
hair cycle
innate immune response
intermediate filament cytoskeleton organization
keratinocyte migration
establishment of skin barrier
