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Invitrogen
Cytomegalovirus UL146 Polyclonal Antibody
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产品信息
PA5-149147
产品规格
种属反应
Virus
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E. coli-derived recombinant viral CMV UL146/vCXC1
偶联物
形式
Lyophilized
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with trehalose
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute at 0.2 mg/mL in sterile PBS.
靶标信息
Cytomegalovirus (CMV) UL146 is a gene encoded by human cytomegalovirus (HCMV), a member of the herpesvirus family that can cause significant disease in immunocompromised individuals and newborns. The UL146 gene is part of a cluster of genes that encode for viral chemokine-like proteins. UL146 specifically encodes a CXC chemokine, vCXCL1, which mimics human chemokines and can bind to chemokine receptors on host cells. This viral chemokine plays a crucial role in modulating the host immune response by attracting neutrophils to the site of infection. By doing so, UL146 can alter the local immune environment, potentially aiding the virus in evading immune detection and promoting viral dissemination. The activity of UL146 is significant in the context of HCMV pathogenesis, as it can contribute to the chronic inflammation and immune dysregulation associated with HCMV infections. Understanding the function and mechanisms of UL146 is essential for developing targeted antiviral therapies and improving strategies to manage HCMV-related diseases. Research into UL146 also provides broader insights into viral immune evasion tactics and the complex interactions between viruses and the host immune system.
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