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Invitrogen
Immunogen sequence: TPAPRQSSPS KSSASHASDP TTDDIFEEGF ESPSKSEEQE APDGSQASSN SDPFGEPSGE PSGDNISPQ
Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 96%.
The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Dab reelin signal transducer 1; Dab, reelin signal transducer, homolog 1; Disabled homolog 1; RP23-356E21.1
基因别名: DAB1
UniProt ID: (Human) O75553
Entrez Gene ID: (Human) 1600
分子生物学功能:
scaffold/adaptor protein
