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Invitrogen
DAF-3 Polyclonal Antibody
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产品信息
PA1-16925
应用
建议稀释比
已发表文章
产品规格
种属反应
C. elegans
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide made to the C-terminus (within residues 700-796) of the C.elegans DAF-3 protein.
偶联物
形式
Liquid
浓度
Conc. Not Determined
保存液
whole serum
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
Signals from TGF-beta superfamily receptors are transduced to the nucleus by Smad proteins, which transcriptionally activate target genes. In Caenorhabditis elegans (C.elegans), defects in a TGF-beta-related pathway cause a reversible developmental arrest and metabolic shift at the dauer larval stage. DAF-3 transgenes interfere with dauer formation, playing a role in the nucleus. DAF-3 is unique in that it is antagonized, rather than activated, by a TGF-beta pathway.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Abnormal dauer formation protein 3; Smad protein; Smad protein daf-3
基因别名: CELE_F25E2.5; daf-3; F25E2.5
UniProt ID: (C. elegans) Q95QI7
Entrez Gene ID: (C. elegans) 180431
RNA polymerase II core promoter proximal region sequence-specific DNA binding
core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
protein binding
transcription factor binding
ubiquitin protein ligase binding
I-SMAD binding
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
transforming growth factor beta receptor signaling pathway
determination of adult lifespan
anatomical structure morphogenesis
cell differentiation
BMP signaling pathway
dauer larval development
regulation of pharyngeal pumping
positive regulation of transcription from RNA polymerase II promoter
defense response to Gram-negative bacterium
SMAD protein signal transduction
regulation of dauer larval development
positive regulation of dauer larval development
cellular response to pheromone
