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This antibody detects endogenous protein at a molecular weight of 244 kDa.
Purity is >95% by SDS-PAGE.
Dio-1 (Death Inducer-Obliterator-1) is a putative transcription factor that contains two zinc finger motifs. Dio-1 translocates to the nucleus, and activates apoptosis during limb development. Programmed cell death, a highly regulated form of apoptosis, plays an important role in determining the amount of tissue, the shape, and the definition of each digit during limb development. Dio-1 expression is upregulated when an apoptotic signal is detected, and subsequently apoptosis is induced. This process is similar to the expression of NFkB and NGF in response to external signals. Dio-1 expression is suppressed by caspase inhibitors and Bcl-2 expression. This supports the theory that Dio-1 functions in the onset of programmed cell death.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: DATF-1; death associated transcription factor 1; death inducer-obliterator-2; death inducer-obliterator-3; Death-associated transcription factor 1; Death-inducer obliterator 1; DIO-1
基因别名: 6720461J16Rik; BYE1; C20orf158; D130048F08Rik; DATF-1; DATF1; dido; DIDO1; DIDO2; DIDO3; DIO-1; DIO1; dJ885L7.8; KIAA0333
UniProt ID: (Human) Q9BTC0, (Mouse) Q8C9B9
Entrez Gene ID: (Human) 11083, (Mouse) 23856, (Rat) 362286
分子生物学功能: general transcription factor