Immunogen sequence: EPLQARADEV AAAPEQIAAD IPEVVVSLAW DESLAPKHPG SRKNMACYCR IPACIAGERR YGTCIYQGRL WAFC
Highest antigen sequence identity to the following orthologs: Mouse - 38%, Rat - 28%.
Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 1, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 3 by only one amino acid. This gene and the gene encoding defensin, alpha 3 are both subject to copy number variation.
蛋白别名: Defensin, alpha 1; defensin, alpha 1, myeloid-related sequence; defensin, alpha 2; HNP-1; HNP-2; HP 1-56; HP-1; HP-2; myeloid-related sequence; Neutrophil defensin 1; Neutrophil defensin 2
基因别名: DEF1; DEFA1; DEFA1B; DEFA2; HNP-1; HP-1; HP1; MRS
UniProt ID: (Human) P59665
Entrez Gene ID: (Human) 1667
分子生物学功能: antimicrobial response protein