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The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Beta-defensins (also designated BDs, or hBDs in human) are small cationic peptides with broad-spectrum antimicrobial activity against a variety of enveloped viruses, fungi and bacteria. Produced in mucosal epithelia and neutrophils of several species, beta-defensins are developmentally regulated. The family of beta-defensin proteins share a common defensin-motif that is characterized by multiple cysteine residues and a highly conserved tertiary structure. Besides playing a significant role in host immune defense, many beta-defensins also are involved in sperm maturation and capacitation. beta-defensin 121 is a 76 amino acid secreted protein that most likely contains a signal peptide sequence that requires cleavage by proteolytic enzymes in order to become biologically active. While expressed at low levels in testis, beta-defensin 121 is abundantly expressed in epididymal caput and corpus and, unlike other beta-defensins, it does not appear to be regulated by androgens.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Beta-defensin 121; Beta-defensin 21; DB121; DEFB-21; Defensin, beta 121; defensin, beta 21
基因别名: DEFB121; DEFB21; ESC42RELC
UniProt ID: (Human) Q5J5C9
Entrez Gene ID: (Human) 245934
分子生物学功能:
antimicrobial response protein
defense/immunity protein