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A suggested positive control is rat brain tissue lysate.
PA5-34403 can be used with blocking peptide PEP-1445.
DELE is a recently identified DAP3-binding protein that is thought to be important in the induction of death receptor-mediated apoptosis. Transfected cells that stably express DELE were found to be susceptible to apoptosis induction by TNF-Alpha and TRAIL, whereas reducing DELE expression by siRNA rescued these cells from apoptosis induction. Furthermore, the reduction of DELE expression also inhibited the activation of caspase-3, caspase-8 and caspase-9 following stimulation by TNF-Alpha, anti-Fas, or TRAIL, indicating the importance of DELE in apoptosis mediated by death receptors.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: DAP3-binding cell death enhancer 1; DAP3-binding cell death enhancer 1, long form; Death ligand signal enhancer; DELE1(L)
基因别名: DELE; DELE1; KIAA0141
UniProt ID: (Human) Q14154
Entrez Gene ID: (Human) 9812