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Immunogen sequence: PLDRFFSSPL WHPCSSLRQH ILPSPDGPAP RHTGLREPRL GQEEASAQPR NFSHNSLRGA RPQDPSEEGP GDFGFLHASS SIESEAKPAQ P
Highest antigen sequence identity to the following orthologs: Mouse - 55%, Rat - 59%.
DELE is a recently identified DAP3-binding protein that is thought to be important in the induction of death receptor-mediated apoptosis. Transfected cells that stably express DELE were found to be susceptible to apoptosis induction by TNF-Alpha and TRAIL, whereas reducing DELE expression by siRNA rescued these cells from apoptosis induction. Furthermore, the reduction of DELE expression also inhibited the activation of caspase-3, caspase-8 and caspase-9 following stimulation by TNF-Alpha, anti-Fas, or TRAIL, indicating the importance of DELE in apoptosis mediated by death receptors.
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