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Proteintech
DENND1A Polyclonal Antibody
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产品信息
25658-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
DENND1A Fusion Protein Ag22547 (451-559 aa encoded by BC039703)
偶联物
形式
Liquid
浓度
0.31 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
This antibody (25658-1-AP) can recognize all isoforms at 112 kDa and 52-64 kDa.
Immunogen sequence: QKDIAENGC APTPEEQLPK TAPSPLVEAK DPKLREDRRP ITVHFGQVRP PRPHVVKRPK SNIAVEGRRT SVPSPEQNTI ATPATLHILQ KSITHFAAKF PTRGWTSSSH (451-559 aa encoded by BC039703)
靶标信息
Clathrin-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1A, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2). Thus, connecdenns link RAB35 activation with the clathrin machinery.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Connecdenn; Connecdenn 1; DENN domain-containing protein 1A; DENN/MADD domain containing 1A; Protein FAM31A; RP11-230L22.3
基因别名: DENND1A; FAM31A; KIAA1608
UniProt ID: (Human) Q8TEH3
Entrez Gene ID: (Human) 57706
