Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%
The protein encoded by this gene belongs to the derlin family, and resides in the endoplasmic reticulum (ER). Proteins that are unfolded or misfolded in the ER must be refolded or degraded to maintain the homeostasis of the ER. This protein appears to be involved in the degradation of misfolded glycoproteins in the ER. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
蛋白别名: Degradation in endoplasmic reticulum protein 3; Der1-like domain family, member 3; Der1-like protein 3; Derlin-3; DERtrin 3; DERtrin-3; MGC71803
基因别名: C22orf14; DER3; DERL3; derlin-3; IZP6; LLN2
UniProt ID: (Human) Q6ZUB5
Entrez Gene ID: (Human) 91319
分子生物学功能: primary active transporter