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Peptide Sequence: SGERKGLREL HRGDWVLAAD ASGRVVPTPV LLFLDRDLQR RASFVAVETE WPPRKLLLTP WHLVFAARGP APAPGDFAPV FARRLRAGDS VLAPGGDALR P*
This gene encodes a member of the Hedgehog family. The hedgehog gene family encodes signaling molecules that play an important role in regulating morphogenesis. This protein is predicted to be made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signaling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the organism. Defects in this protein have been associated with partial gonadal dysgenesis (PGD) accompanied by minifascicular polyneuropathy. This protein may be involved in both male gonadal differentiation and perineurial development.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
Protein Aliases: Desert hedgehog protein; Desert hedgehog protein N-product; DHH; DHH-N; HHG-3
Gene Aliases: DHH; GDXYM; HHG-3; SRXY7
UniProt ID: (Human) O43323
Entrez Gene ID: (Human) 50846
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