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Invitrogen
DLK1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-102649
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human DLK1(Accession P80370), corresponding to amino acid residues S155-C205.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total DLK1.
靶标信息
The Delta-like 1 homolog (DLK1) is a transmembrane protein containing six epidermal growth factor repeats. It is involved in the differentiation of several cell types, including adipocytes and is also thought to be a tumor suppressor. The DLK1 gene is one of several imprinted genes located in a region on chromosome 14q32; certain mutations in this imprinted region can cause phenotypes similar to maternal and paternal uniparental disomy of chromosome 14 (UPD14). DLK1 is expressed from the paternal allele; a polymorphism within this gene has been associated with child and adolescent obesity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: adenoma-associated variant of dlk1 protein; adipocyte differentiation inhibitor protein; alternatively spliced; lacking 219 bp between positions 858 and 859; The 219 bp deletion has been demonstrated to originate by alternative splicing within an exon.; delta-like 1 homolog; dlk; EGF like function; fetal antigen 1; preadipocyte factor 1; PREF; secredeltin; similar to Drosophila; stromal cell derived protein 1; transmembrane domain encoded by 1099-1167.; unnamed protein product; ZOG
基因别名: Delta1; DLK; DLK-1; DlkI; FA1; Ly107; Peg9; pG2; Pref-1; PREF1; SCP1; ZOG
UniProt ID: (Human) P80370, (Mouse) Q09163, (Rat) O70534
Entrez Gene ID: (Human) 8788, (Mouse) 13386, (Rat) 114587
ossification
osteoblast differentiation
positive regulation of cytokine production
post-embryonic development
regulation of gene expression
cell differentiation
negative regulation of ossification
bone mineralization
multicellular organism growth
negative regulation of cell differentiation
regulation of fat cell differentiation
negative regulation of fat cell differentiation
negative regulation of osteoblast differentiation
positive regulation of osteoclast differentiation
negative regulation of Notch signaling pathway
positive regulation of bone resorption
regulation of bone remodeling
embryonic skeletal system development
negative regulation of vascular endothelial cell proliferation
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