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Positive Control: MCF7 cell lysate, HepG2 cell lysate, SH-SY5Y cell lysate, mouse placenta tissue lysate, rat embryo tissue lysate, human pancreas tissue, mouse brain tissue, rat brain tissue.
Tissue Specificity: Group enriched (adrenal gland, pituitary gland, placenta).
Subcellular Location: Membrane, Cytoplasm.
Sequence Similarities: 83% Mouse/Rat.
Predicted band size: 41 kDa
The Delta-like 1 homolog (DLK1) is a transmembrane protein containing six epidermal growth factor repeats. It is involved in the differentiation of several cell types, including adipocytes and is also thought to be a tumor suppressor. The DLK1 gene is one of several imprinted genes located in a region on chromosome 14q32; certain mutations in this imprinted region can cause phenotypes similar to maternal and paternal uniparental disomy of chromosome 14 (UPD14). DLK1 is expressed from the paternal allele; a polymorphism within this gene has been associated with child and adolescent obesity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Adipocyte differentiation inhibitor protein; delta-like 1 homolog; DLK-1; fetal antigen 1; pG2; Preadipocyte factor 1; preadipocyte factor-1; PREF; Pref-1; Protein delta homolog 1; secredeltin; stromal cell derived protein 1
基因别名: AW742678; Delta1; DLK; DLK-1; DLK1; DlkI; FA1; Ly107; Peg9; pG2; Pref-1; PREF1; Scp-1; SCP1; ZOG
UniProt ID: (Human) P80370, (Mouse) Q09163, (Rat) O70534
Entrez Gene ID: (Human) 8788, (Mouse) 13386, (Rat) 114587