Search
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Proteintech
DMAP1 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
产品信息
10411-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
DMAP1 Fusion Protein Ag0665 (1-467 aa encoded by BC002855)
偶联物
形式
Liquid
浓度
0.29 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
The antibody reacts specifically with DMAP1 protein.
Immunogen sequence: MATGADVRD ILELGGPEGD AASGTISKKD IINPDKKKSK KSSETLTFKR PEGMHREVYA LLYSDKKDAP PLLPSDTGQG YRTVKAKLGS KKVRPWKWMP FTNPARKDGA MFFHWRRAAE EGKDYPFARF NKTVQVPVYS EQEYQLYLHD DAWTKAETDH LFDLSRRFDL RFVVIHDRYD HQQFKKRSVE DLKERYYHIC AKLANVRAVP GTDLKIPVFD AGHERRRKEQ LERLYNRTPE QVAEEEYLLQ ELRKIEARKK EREKRSQDLQ KLITAADTTA EQRRTERKAP KKKLPQKKEA EKPAVPETAG IKFPDFKSAG VTLRSQRMKL PSSVGQKKIK ALEQMLLELG VELSPTPTEE LVHMFNELRS DLVLLYELKQ ACANCEYELQ MLRHRHEALA RAGVLGGPAT PASGPGPASA EPAVTEPGLG PDPKDTIIDV VGAPLTPNSR KRRESASSSS SVKKAKKP (1-467 aa encoded by BC002855)
靶标信息
DNA methyltransferase 1-associated protein 1 (DMAP1) is involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The protein also specifically potentiates DAXX-mediated repression of glucocorticoid receptor-dependent transcription. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. DMAP1 is found in a wide variety of living organisms from yeasts to humans. The human DMAP1 gene is localized on chromosome 1p34.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: DKFZp686L09142; DNA methyltransferase 1-associated protein 1; DNMAP1; DNMT1 associated protein 1; DNMT1 associated protein-1; DNMT1-associated protein 1; FLJ11543; MAT1-mediated transcriptional repressor; RP5-891H21.2
基因别名: 1500016M21Rik; DMAP1; Dmtap1; DNMAP1; DNMTAP1; EAF2; KIAA1425; MEAF2; mKIAA1425; Mmtr; SWC4
UniProt ID: (Human) Q9NPF5, (Mouse) Q9JI44
Entrez Gene ID: (Human) 55929, (Mouse) 66233, (Rat) 298447
negative regulation of transcription from RNA polymerase II promoter
DNA repair
DNA methylation
chromatin remodeling
transcription, DNA-templated
regulation of growth
positive regulation of transcription factor import into nucleus
histone H4 acetylation
histone H2A acetylation
response to ethanol
negative regulation of transcription, DNA-templated
regulation of transcription, DNA-templated
chromatin modification
methylation
