Immunogen sequence: FTGEADQAPG VEPGDIVLLL QEKEHEVFQR DGNDLHMTYK IGLVEALCGF QFTFKHLDGR QIVVKYPPGK VIEPGCVRVV RGEGMPQYRN PFEKGDLYIK FDVQFPENNW INPDKLSELE DLLPSRPEVP NIIGETEEVE LQEFDSTRGS GGGQRREAYN DSSDEESSSH HGPGVQCAHQ; Positive Samples: A-375, 293T, HepG2, MCF7, Mouse kidney, Mouse heart, Mouse brain; Cellular Location: Lipid-anchor, Membrane
The protein encoded by this gene belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus; a glycine/phenylalanine (G/F)-rich region; and a cysteine-rich domain containing 4 motifs resembling a zinc finger domain. The product of this gene works as a cochaperone of Hsp70s in protein folding and mitochondrial protein import in vitro.
蛋白别名: cell cycle progression 3 protein; Cell cycle progression restoration gene 3 protein; Dj3; DNA J protein; DnaJ (Hsp40) homolog, subfamily A, member 2; DnaJ homolog subfamily A member 2; Dnj3; HIRA interacting protein 4; HIRA-interacting protein 4; mDj3; Renal carcinoma antigen NY-REN-14
基因别名: 1500017M13Rik; 2010206B19Rik; CPR3; DJ3; DJA2; DNAJ; Dnaj3; DNAJA2; DNJ3; HIRIP4; mDj3; PRO3015; RDJ2