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Immunogen sequence: RKPSGSGDQS KPNCTKDSTS GSGEGGKGYT KDQVDGVLSI NKCKNYYEVL GVTKDAGDED
Highest antigen sequence identity to the following orthologs: Mouse - 87%, Rat - 85%.
Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway (PubMed:24732912). Acts by determining HSPA8/Hsc70's ATPase and polypeptide-binding activities (PubMed:24732912). Can also act independently of HSPA8/Hsc70: together with DNAJB12, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and assembling them into tetramers (PubMed:27916661). While stabilization of nascent channel proteins is dependent on HSPA8/Hsc70, the process of oligomerization of channel subunits is independent of HSPA8/Hsc70 (PubMed:27916661). When overexpressed, forms membranous structures together with DNAJB12 and HSPA8/Hsc70 within the nucleus; the role of these structures, named DJANGOs, is still unclear (PubMed:24732912). [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: DnaJ (Hsp40) homolog, subfamily B, member 14; DnaJ homolog subfamily B member 14
基因别名: 5730496F10Rik; DNAJB14; EGNR9427; PRO34683; UNQ9427/PRO34683
UniProt ID: (Human) Q8TBM8, (Mouse) Q149L6
Entrez Gene ID: (Human) 79982, (Mouse) 70604, (Rat) 499716