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Proteintech
DOCK10 Polyclonal Antibody
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产品信息
16834-1-AP
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
DOCK10 Fusion Protein Ag10486 (194-542 aa encoded by BC015018)
偶联物
形式
Liquid
浓度
0.13 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: AVFEKQRDF KKLSDLYYDI HRSYLKVAEV VNSEKRLFGR YYRVAFYGQG FFEEEEGKEY IYKEPKLTGL SEISQRLLKL YADKFGADNV KIIQDSNKVN PKDLDPKYAY IQVTYVTPFF EEKEIEDRKT DFEMHHNINR FVFETPFTLS GKKHGGVAEQ CKRRTILTTS HLFPYVKKRI QVISQSSTEL NPIEVAIDEM SKKVSELNQL CTMEEVDMIR LQLKLQGSVS VKVNAGPMAY ARAFLEETNA KKYPDNQVKL LKEIFRQFAD ACGQALDVNE RLIKEDQLEY QEELRSHYKD MLSELSTVMN EQITGRDDLS KRGVDQTCTR VISKATPALP TVSISSSAEV (194-542 aa encoded by BC015018)
靶标信息
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Overexpression of this gene results in a decrease in the processing of insulin and hepatocyte growth factor receptors to their mature subunits. This decrease is caused by the mislocalization of furin, the endoprotease responsible for cleavage of insulin and hepatocyte growth factor receptors. This protein is involved in endosomal trafficking from the plasma membrane to recycling endosomes or the trans-Golgi network. This gene encodes two transcript variants encoding distinct isoforms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: dedicator of cytokinesis 10; Dedicator of cytokinesis protein 10; dopamine receptor interacting protein 2; Zizimin-3; zizimin3
基因别名: 9330153B10Rik; A630054M16Rik; DOCK10; DRIP2; Jr4; Jr5; KIAA0694; mKIAA0694; Nbla10300; R75174; RGD1561963; ZIZ3; Zizimin3
UniProt ID: (Human) Q96BY6, (Mouse) Q8BZN6
Entrez Gene ID: (Human) 55619, (Mouse) 210293, (Rat) 301556
