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Invitrogen
DOK7 Polyclonal Antibody
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DOK7 Antibody (PA5-95620) in IHC (P)
Immunohistochemistry (Paraffin) analysis of DOK7 in paraffin-embedded section of human skeletal muscle tissue using DOK7 Polyclonal Antibody (Product # PA5-95620). Heat mediated antigen retrieval was performed in EDTA buffer (pH 8.0, epitope retrieval solution). The tissue section was blocked with 10% goat serum. The tissue section was then incubated with the primary antibody at a 2 µg/mL dilution overnight... View More
产品信息
PA5-95620
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence of human DOK7 (STVEERVAQEALETLQLEKRLSLLSHAGR).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Affinity chromatography
保存液
PBS with 4mg trehalose
内含物
no preservative
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: human MCF-7 whole cell, human RT4 whole cell, rat skeletal muscle tissue lysates, rat brain tissue lysates, rat heart tissue lysates, rat L6 whole cell lysates, mouse skeletal muscle tissue lysates, mouse brain tissue lysates, mouse heart tissue lysates, mouse C2C12 whole cell lysates. IHC: human skeletal muscle, rat heart. Flow: RT4 cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
靶标信息
The protein encoded by this gene is essential for neuromuscular synaptogenesis. The protein functions in aneural activation of muscle-specific receptor kinase, which is required for postsynaptic differentiation, and in the subsequent clustering of the acetylcholine receptor in myotubes. This protein can also induce autophosphorylation of muscle-specific receptor kinase. Mutations in this gene are a cause of familial limb-girdle myasthenia autosomal recessive, which is also known as congenital myasthenic syndrome type 1B. Alternative splicing results in multiple transcript variants.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Downstream of tyrosine kinase 7; oncoprotein induced transcript 5; Protein Dok-7
基因别名: A930013K19Rik; AW049091; C4orf25; CMS10; CMS1B; Dok-7; DOK7; EF-12; Oit5; RGD1566416
UniProt ID: (Human) Q18PE1, (Mouse) Q18PE0
Entrez Gene ID: (Human) 285489, (Mouse) 231134, (Rat) 305448
