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Immunogen sequence: MASSSGNDDD LTIPRAAINK MIKETLPNVR VANDARELVV NCCTEFIHLI SSEANEICNK SEKKTISPEH VIQALESLGF GSYISEVKEV LQECKTVALK RRKASSRLEN LGIPEEELLR QQQELFAKAR QQQAELAQQE WLQMQQAAQQ AQLAAASASA SNQAGSSQDE EDDDDI; Positive Samples: Mouse spleen; Cellular Location: Nucleus
This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Down-regulator of transcription 1; down-regulator of transcription 1, TBP-binding (negative cofactor 2); NC2-beta; negative cofactor 2; negative cofactor 2 beta; Negative cofactor 2-beta; Protein Dr1; TATA-binding protein-associated phosphoprotein
基因别名: 1700121L09Rik; DR1; Dr1l; NC2; NC2-BETA; NC2B; NC2beta
UniProt ID: (Human) Q01658, (Mouse) Q91WV0
Entrez Gene ID: (Human) 1810, (Mouse) 13486