Invitrogen

DR4 Monoclonal Antibody (DR-4-02), FITC

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DR4 Antibody in Flow Cytometry (Flow) — Figure 4. Effects of TRAIL-Mu3 on the expression levels and distribution of DRs. (A) TRAIL-Mu3 upregulated DR4 and DR5 expression in PANC-1 cells. *P<0.001 vs. TRAIL. (B) TRAIL-Mu3 and TRAIL had no effect on the distribution of DR4 in lipid rafts, while (C) TRAIL-Mu3 promoted DR5 clustering into lipid rafts. Lipid rafts were stained with FITC-conjugated rabbit anti-Ctx (green) and DR4/DR5 was counterstained with rhodamine (red). Scale bar, 20 um. TRAIL-Mu3, recombinant TNF-related apoptosis-inducing ligand; DR, death receptor; Ctx, choleratoxin B.

产品信息

A15746

应用	建议稀释比	已发表文章
流式细胞分析 (Flow)	Assay-dependent	View 1 publication 1 publication

产品规格
种属反应	Human
已发表种属	Not Applicable
宿主/亚型	Mouse / IgG1
分类	Monoclonal
类型	Antibody
克隆号	DR-4-02
抗原	Human CD261
偶联物	FITC APC Unconjugated
激发/发射光谱	查看光谱
形式	Liquid
浓度	0.1 mg/mL
纯化类型	purified
保存液	PBS, pH 7.4, with 0.2% BSA
内含物	15mM sodium azide
保存条件	4° C, store in dark
RRID	AB_2534526

靶标信息

TRAIL-R1 (CD261, DR4) is a type I transmembrane protein, also called TRAIL receptor 1. The ligand for this DR4 death receptor has been identified and termed TRAIL, which is a member of the TNF family. DR4, as many other receptors (Fas, TNFR1, etc.), mediates apoptosis and NF kappaB activation in many cells and tissues. Apoptosis, a programmed cell death, is a operating process in normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by coupled of certain cytokines (TNF family - TNF, Fas ligand) and their death domain containing receptors (TNFR1, Fas receptor).

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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Product References

Recombinant protein TRAIL-Mu3 enhances the antitumor effects in pancreatic cancer cells by strengthening the apoptotic signaling pathway.

Oncology letters

Huang M,Yi C,Huang XZ,Yan J,Wei LJ,Tang WJ,Chen SC,Huang Y

Published figure using DR4 monoclonal antibody (Product # A15746) in Flow Cytometry

Tue Jun 01 00:00:00 EDT 2021

生物信息学

蛋白别名: CD261; cytotoxic TRAIL receptor; Death receptor 4; MGC9365; sCD261; soluble CD261; soluble TRAIL; sTRAIL; TNF-related apoptosis-inducing ligand receptor 1; TRAIL R1; TRAIL receptor 1; TRAIL-R1; Tumor necrosis factor receptor superfamily member 10A; tumor necrosis factor receptor superfamily member 10a variant 2; tumor necrosis factor receptor superfamily, member 10a

基因别名: APO2; CD261; DR4; TNFRSF10A; TRAILR-1; TRAILR1

UniProt ID: (Human) O00220

Entrez Gene ID: (Human) 8797

分子生物学功能: transmembrane signal receptor

功能

apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process inflammatory response immune response signal transduction cell surface receptor signaling pathway activation of NF-kappaB-inducing kinase activity multicellular organism development extrinsic apoptotic signaling pathway via death domain receptors response to lipopolysaccharide tumor necrosis factor-mediated signaling pathway TRAIL-activated apoptotic signaling pathway regulation of cell proliferation regulation of apoptotic process cellular response to mechanical stimulus extrinsic apoptotic signaling pathway activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

参与通路

protease binding receptor activity tumor necrosis factor-activated receptor activity death receptor activity protein binding transcription factor binding TRAIL binding

DR4 Monoclonal Antibody (DR-4-02), FITC

产品信息

A15746

流式细胞分析 (Flow)

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偶联物

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保存液

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