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PA1-30554 detects DR6 from human samples.
PA1-30554 has been successfully used in Western blot applications.
The PA1-30554 immunogen is: Peptide corresponding to amino acids 42-56 of human DR6 precursor.
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DR6 is widely expressed in human tissues and cell lines. The ligand for DR6 has not been identified. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several novel death receptors including DR3, DR4, and DR5 were recently identified. A new death domain containing receptor in the TNFR family was cloned recently and termed DR6 for death receptor-6. Like TNF-R1, DR6 interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-kappa-B and JNK.
仅用于科研。不用于诊断过程。未经明确授权不得转售。