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Invitrogen
DR6 Monoclonal Antibody (DR-6-04-EC), FITC
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产品信息
MA5-28618
产品规格
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
DR-6-04-EC
抗原
Human DR6 (aa 42-335, extracellular region)
偶联物
激发/发射光谱
498/517 nm
查看光谱
形式
Liquid
浓度
1 mg/mL
保存条件
4°C, store in dark, DO NOT FREEZE!
运输条件
Wet ice
RRID
产品详细信息
The antibody DR-6-04-EC recognizes human DR6 (Death receptor-6), a type I transmembrane protein containing cytoplasmic death domain, widely expressed in most human tissues and cell lines.
靶标信息
DR6 is widely expressed in human tissues and cell lines. The ligand for DR6 has not been identified. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several novel death receptors including DR3, DR4, and DR5 were recently identified. A new death domain containing receptor in the TNFR family was cloned recently and termed DR6 for death receptor-6. Like TNF-R1, DR6 interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-kappa-B and JNK.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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