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Invitrogen
DRD3 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-79170
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence at the C-terminus of human Dopamine Receptor D3 (352-367aa NTHCQTCHVSPELYSA).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
500 µg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
0.9mg NaCl, 0.2mg Na2PO4, 4mg trehalose
内含物
0.01mg sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: Rat Testis Tissue, Rat Brain Tissue, U87 Cell, HELA Cell. IHC: Rat Brain Tissue.
靶标信息
This gene encodes the D3 subtype of the five (D1-D5) dopamine receptors. The activity of the D3 subtype receptor is mediated by G proteins which inhibit adenylyl cyclase. This receptor is localized to the limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functions. Genetic variation in this gene may be associated with susceptibility to hereditary essential tremor 1. Alternative splicing of this gene results in transcript variants encoding different isoforms, although some variants may be subject to nonsense-mediated decay (NMD).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: D(3) dopamine receptor; D3nf; Dopamine 3 receptor; Dopamine D3 receptor; dopamine receptor 3; dopaminergic receptor D3; essential tremor 1; unnamed protein product
基因别名: D3DR; D3R; DRD3; ETM1; FET1
Entrez Gene ID: (Human) 1814, (Mouse) 13490, (Rat) 29238
negative regulation of transcription from RNA polymerase II promoter
synaptic transmission, dopaminergic
response to amphetamine
regulation of blood volume by renin-angiotensin
G-protein coupled receptor internalization
cellular calcium ion homeostasis
autophagy
G-protein coupled receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
adenylate cyclase-activating dopamine receptor signaling pathway
adenylate cyclase-inhibiting dopamine receptor signaling pathway
dopamine receptor signaling pathway
locomotory behavior
positive regulation of cell proliferation
visual learning
response to xenobiotic stimulus
regulation of gene expression
regulation of dopamine secretion
regulation of lipid metabolic process
positive regulation of cytokinesis
circadian regulation of gene expression
response to histamine
regulation of multicellular organism growth
response to cocaine
negative regulation of apoptotic process
regulation of potassium ion transport
response to morphine
regulation of circadian sleep/wake cycle, sleep
response to ethanol
negative regulation of G-protein coupled receptor protein signaling pathway
negative regulation of blood pressure
positive regulation of mitotic nuclear division
positive regulation of transcription from RNA polymerase II promoter
acid secretion
behavioral response to cocaine
negative regulation of oligodendrocyte differentiation
arachidonic acid secretion
negative regulation of protein secretion
musculoskeletal movement, spinal reflex action
regulation of multicellular organismal process
negative regulation of cytosolic calcium ion concentration
regulation of neurotransmitter uptake
negative regulation of protein kinase B signaling
negative regulation of synaptic transmission, glutamatergic
prepulse inhibition
phospholipase C-activating dopamine receptor signaling pathway
negative regulation of dopamine receptor signaling pathway
positive regulation of dopamine receptor signaling pathway
regulation of locomotion involved in locomotory behavior
regulation of postsynaptic neurotransmitter receptor internalization
negative regulation of sodium ion import across plasma membrane
learning or memory
learning
social behavior
dopamine metabolic process
regulation of dopamine uptake involved in synaptic transmission
regulation of amine transport
regulation of secretion by cell
regulation of locomotion
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