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Progen
DSC1 Monoclonal Antibody (Dsc1-U100)
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产品信息
61092PROGEN
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
Dsc1-U100
抗原
Synthetic Peptide Corresponding To Sequence Present Within The Intracellular Part Of Human Desmocollin 1 (Hqtlesvkgv gqgdtgryat dwqc)
偶联物
形式
Lyophilized
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 0.5% BSA
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitute lyophilized product with 1 mL distilled water.
Localizes Dsc1 present insuprabasal layers of interfollicular epidermisspecific cell layers (e.g. in hair follicle root sheath)Hassall bodies (spheroidal formations of densely packed reticulum-derived cells in the thymus).Reacts with 111 kD (form "a") and 103 kD (form "b") polypeptides (desmo-collin 1 splice forms, both at pI 5.2) from human epidermal desmosomes.Reactivity on cultured cell lines: Positive on primary keratinocytes, however, restricted to local piles of differentiated cells. All simple epithelia are negative.
靶标信息
The desmosomal cadherin desmocollin DSC1 is expressed in upper epidermis where strong adhesion is required. DSC1 is a type I membrane protein (4) required for strong adhesion and barrier maintenance in epidermis and contributes to epidermal differentiation.The DSC1 gene comprises 17 exons spanning approximately 33 kb on 18q12.1.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cadherin family member 1; Desmocollin-1; Desmocollin1; Desmosomal glycoprotein 2/3; DG2/DG3
基因别名: 1110020A10Rik; AI507491; CDHF1; DG2/DG3; DSC1; Dsc1a; Dsc1b
UniProt ID: (Human) Q08554, (Mouse) P55849
Entrez Gene ID: (Human) 1823, (Rat) 291759, (Mouse) 13505
