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Alomone Labs, LTD
DSCAM (extracellular) Polyclonal Antibody
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DSCAM (extracellular) Antibody (ANR-046-200UL) in IHC (F)
Expression of DSCAM in rat cerebellum. Immunohistochemical staining of perfusion-fixed frozen rat brain sections with Anti-DSCAM (extracellular) Antibody (#ANR-046) (1:300), followed by goat anti-rabbit-AlexaFluor-488. A. DSCAM immunoreactivity (green), appears in cells of the Purkinje layer (arrows) and distributed diffusely in the molecular layer (M). B. Pre-incubation of the antibody with DSCAM (extracel... View More
产品信息
ANR-046-200UL
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptide DGVLVSTQDSRIKQLE, corresponding to amino acid residues 491-506 of human Robo1. Extracellular, N-term.
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Immunogen sequence: DGVLVSTQDSRIKQLE
Reconstitution: 25 uL, 50 uL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
This gene is a member of the immunoglobulin superfamily of cell adhesion molecules (Ig-CAMs), and is involved in human central and peripheral nervous system development. This gene is a candidate for Down syndrome and congenital heart disease (DSCHD). A gene encoding a similar Ig-CAM protein is located on chromosome 11. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012].
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cell adhesion molecule DSCAM; CHD2; Down syndrome cell adhesion molecule; Down syndrome cell adhesion molecule homolog
基因别名: 4932410A21Rik; CHD2; CHD2-42; CHD2-52; DSCAM
UniProt ID: (Human) O60469, (Rat) Q8VHZ8, (Mouse) Q9ERC8
Entrez Gene ID: (Human) 1826, (Rat) 171119, (Mouse) 13508
cell adhesion
homophilic cell adhesion via plasma membrane adhesion molecules
negative regulation of cell adhesion
nervous system development
synapse assembly
locomotory behavior
retina layer formation
positive regulation of phosphorylation
dendrite morphogenesis
positive regulation of axon extension involved in axon guidance
post-embryonic retina morphogenesis in camera-type eye
camera-type eye photoreceptor cell differentiation
dendrite self-avoidance
