FIGURE: 1 / 1
Peptide sequence: VNQISGAHNT SDKQTPSKPK KKQNSKGLAP SVDFQQSVTV VLFQDENTLV
Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 86%; Rat: 100%
Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1 and CDKN1A/p21(CIP1). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis.
Protein Aliases: DDB1 and CUL4 associated factor 2; DDB1- and CUL4-associated factor 2; Denticleless protein homolog; Lethal(2) denticleless protein homolog; RA regulated nuclear matrix associated protein; RA-regulated nuclear matrix-associated protein; Retinoic acid-regulated nuclear matrix-associated protein
Gene Aliases: CDT2; CDW1; DCAF2; DTL; L2DTL; RAMP
UniProt ID: (Human) Q9NWM5
Entrez Gene ID: (Human) 51514