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Invitrogen
DTX1/DTX4 Monoclonal Antibody (730612)
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产品信息
MA5-61770
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
730612
抗原
E. coli-derived recombinant human DTX1/DTX4, Met1-Phe147
偶联物
形式
Lyophilized
浓度
0.5 mg/mL
纯化类型
Protein A/G
保存液
PBS with trehalose
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with sterile PBS to a final concentration of 0.5 mg/mL.
靶标信息
DTX1 (Deltex 1) and DTX4 (Deltex 4) are genes that encode members of the Deltex family of E3 ubiquitin ligases, which play crucial roles in the regulation of the Notch signaling pathway. Notch signaling is a highly conserved cellular communication system that is fundamental to cell differentiation, proliferation, and apoptosis. DTX1 and DTX4 function by tagging specific proteins with ubiquitin, marking them for degradation by the proteasome, thereby modulating the intensity and duration of Notch signaling. These genes are involved in various developmental processes and have been implicated in the regulation of immune cell development, including T cells and B cells. Aberrations in the expression or function of DTX1 and DTX4 can lead to dysregulation of Notch signaling, which is associated with several pathological conditions such as cancer, particularly T-cell acute lymphoblastic leukemia, and other disorders involving abnormal cell growth and differentiation. Understanding the roles of DTX1 and DTX4 in Notch signaling and their broader biological functions is essential for developing targeted therapies aimed at correcting Notch pathway dysregulation in various diseases. Research into these genes offers insights into their potential as therapeutic targets and biomarkers for disease diagnosis and treatment.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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