FIGURE: 1 / 1
This antibody is predicted to react with bovine, canine, mouse and rat based on sequence homology.
Dual-specificity phosphatases constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. DUSP16 belongs to a class of DUSPs, designated MKPs, that dephosphorylate MAPK proteins ERK, JNK, and p38 with specificity distinct from that of individual MKP proteins. MKPs contain a highly conserved C-terminal catalytic domain and an N-terminal Cdc25-like domain. MAPK activation cascades mediate various physiologic processes, including cellular proliferation, apoptosis, differentiation, and stress responses.
Protein Aliases: Dual specificity protein phosphatase 16; MAP kinase phosphatase 7; MAPK phosphatase-7; MGC129701; MGC129702; Mitogen-activated protein kinase phosphatase 7
Gene Aliases: DUSP16; KIAA1700; MKP-7; MKP7
UniProt ID: (Human) Q9BY84
Entrez Gene ID: (Human) 80824
Molecular Function: protein phosphatase